https://www.xiaolabatyale.org/home daily 1.0 2021-09-08 https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1631067860849-BFMCAS5UUQC1MKCLOQ1G/Centromeres+in+cancer+cells_2.jpg Home - Our Research Our lab is interested in understanding how epigenetic mechanisms - such as DNA methylation and histone modifications - are involved in both mammalian development and disease. We aim to uncover how epigenetic regulators function at a basic science level with the goal of exploiting these mechanisms in the treatment of diseases such as cancer. https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1592926081586-19JQLDBR7PEBG84IOC0G/Lab+pic.png Home - Meet the Lab Located at the Yale School of Medicine, the Xiao lab is affiliated with the Yale Cancer Center, the Yale Stem Cell Center, and the Biological and Biomedical Sciences Graduate Program. https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1593017879785-LW5OBYQAGMN9HI7B9S7P/YSM.jpg Home - News Check out the latest Xiao lab news! https://www.xiaolabatyale.org/publications daily 0.75 2020-07-15 https://www.xiaolabatyale.org/research daily 0.75 2022-09-07 https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1592959919061-0ZNUWJ5O1JKSMANXA6A6/ESC+to+TSC+diagram.png Research Embryonic stem cell (ESC) to trophoblast stem cell (TSC) system (Li et al., Nature, 2020) https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1592958846793-NUM3QAUS644GZXBRBNK0/N6-mA+in+glioblastoma.png Research Diagram of the role of 6mA in glioblastoma progression. Image from Xie et al., Cell, 2018. https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1594307213196-XF5BWG01HHXK81ZBJQBY/EA1+lamin+6mA_z0.jpg Research Mouse embryonic stem cells stained with DAPI (blue), lamin (green), and 6mA (red) antibodies. Image taken by Raman. https://www.xiaolabatyale.org/people daily 0.75 2025-07-09 https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1621865767676-WIVSXT010X109NTKT4CX/Yichen+Li.jpeg People https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1592927922379-EO03JGBTRIG6HWOVFD22/YMS2612_0365_A_Xiao-Edit.jpg People https://images.squarespace-cdn.com/content/v1/5ef21632bb9bf43c0bc7a41a/1619211344811-EDD6KOL4DN82XRPZTIYD/Rana.jpg People https://www.xiaolabatyale.org/news daily 0.75 2025-07-09 https://www.xiaolabatyale.org/contact daily 0.75 2023-08-07 https://www.xiaolabatyale.org/open-positions daily 0.75 2020-11-07 https://www.xiaolabatyale.org/alumni daily 0.75 2025-07-09 https://www.xiaolabatyale.org/contact-1 daily 0.75 2025-06-10